Troperitoneum recurred in nearly all cases (21 of 23 cases), occasionally caused patient death, and dedifferentiated in four cases (median time to dedifferentiation, 8 years). buy viagra canada Tumors in the groin had a similar high recurrence rate (11 of 14 cases), caused death of patients (two of 14 cases), and dedifferentiated (four of 14 cases). generic viagra online In contrast, those in the extremity recurred less frequently (20 of 46 cases) and had no disease-related mortality. Three of 46, however, underwent dedifferentiation (median time to dedifferentiation, 7 years). Of the 11 cases that underwent dedifferentiation, the interval between diagnosis and dedifferentiation ranged from 2 to 18 years (median time, 9 years; average time, 11 years). liquid viagra dosage Six of the 11 patients showed dedifferentiated foci in the first recurrence, and three died of metastatic disease. Our study indicates that the behavior of well-differentiated liposarcomas is strongly influenced by location. buying generic viagra online illegal Although the prevailing view is that dedifferentiation is restricted to tumors of the retroperitoneum, our study indicates that it is not a site-specific phenomenon, but is more likely a time-dependent phenomenon seen in situations with a high likelihood for clinical persistence of disease for a long period. best pharmacy price viagra Dedifferentiation identifies a tumor that is potentially more aggressive; yet the progression of the disease following dedifferentiation may be highly variable and probably depends on a number of factors, including the amount of dedifferentiation and type of therapy. Although atypical lipoma is an acceptable term for well-differentiated liposarcomas of the subcutis, it fails to convey the potentially life-threatening properties of retroperitoneal tumors. liquid viagra dosage For these lesions as well as those in the deep soft tissues of the extremity, retention of the term well-differentiated liposarcoma is advocated. Pmid: 1471725 [pubmed - indexed for medline] mesh terms mesh terms adult aged aged, 80 and over cell differentiation extremities* female follow-up studies humans liposarcoma/mortality liposarcoma/pathology* male middle aged neoplasm metastasis neoplasm recurrence, local retroperitoneal neoplasms/pathology* soft tissue neoplasms/mortality soft tissue neoplasms/pathology* survival analysis time factors linkout - more resources full text sources ovid technologies, inc. Supplemental content save items add to favorites loading related citations in pubmed atypical and malignant neoplasms showing lipomatous differentiation. A study of 111 cases. [am j surg pathol. how fast does daily viagra work 1987] atypical and malignant neoplasms showing lipomatous differentiation. A study of 111 cases. cheap viagra online Azumi n, curtis j, kempson rl, hendrickson mr. generic viagra without no rx Am j surg pathol. 1987 mar; 11(3):161-83. Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. [am j surg pathol. liquid viagra dosage 1997] dedifferentiated liposarcoma: a clinicopathological analysis of cardinal cases with a pr.